Multimerization of the Ligand Binding Domains of Cyclic Nucleotide-Gated Channels
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چکیده
منابع مشابه
Multimerization of the Ligand Binding Domains of Cyclic Nucleotide-Gated Channels
Cyclic nucleotide-gated (CNG) channels comprise four subunits and are activated by the direct binding of cyclic nucleotide to an intracellular domain on each subunit. This ligand binding domain is thought to contain a beta roll followed by two alpha helices, designated the B and C helices. To examine the quaternary structure of CNG channels and how it changes during ion channel gating, we intro...
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ژورنال
عنوان ژورنال: Neuron
سال: 2002
ISSN: 0896-6273
DOI: 10.1016/s0896-6273(02)00878-4